陈志刚 

博士、博导,南京农业大学教授。中国第一位发芽糙米研究生。

研究方向:生物催化与转化、全谷物功能性食品研究

个人简介

2006年博士毕业于华南理工大学。2009年-2010年在南京大学生科院医药生物技术国家重点实验室从事博士后研究,合作导师谭仁祥教授。2011-2012年在英国Manchester University做访问学者,合作导师国际著名生化学者Nigel Scrutton教授。

主讲本科生《农产品加工学》、《食品加工贮运学》等专业核心课程;研究生《植物蛋白加工进展》等课程。

科研情况

2014年获得江苏省高校“青蓝工程”中青年学术带头人荣誉和资助。

主要研究方向:

1、食品功能成分(或天然活性产物)富集、分离纯化、分子修饰、生物活性及相关构效关系;

2、(天然活性产物)生物催化与生物转化;

3、农副产品精深加工。

主持和参与国家自然科学基金、教育部、江苏省及其他省部级基金多项。多次与企业合作开发新产品,具有丰富的从产品研发到市场转化经验。 

共发SCI论文多篇;第一作者IF大于5.0的SCI论论2篇,最高影响因子为5.836(Green Chemistry, 2009, 11: 1743–1745),这是食品院建院以来第一篇IF突破5.0的研究论文;另1篇为Bioreource Technology(IF 5.039, 2013, 133: 82-86)。目前为止,发表的SCI论文被引用的次数达100余次。申请国家发明专利30余项,获得授权的国家发明专利10余项。

对天然活性化成分(如魔芋葡苷聚糖、百合多糖、穿心莲内酯及虫草素等)的分离纯化、酶法修饰及相关活性研究发表在SCI期刊上,并受到同行的好评。相关研究成果被国际化学类影响因子最高杂志(2次)Chemical Reviews(IF 35.957)及国际知名的生物大分子类杂志(1次)Biomacromolecules评述及引用(详见Fred van Rantwijk and Roger A. Sheldon. Chemical Reviews, 2007, 107: 2757- 2785;Kobayashi S and Makino A. Chemical Reviews, 2009, 109: 5288–5353; EI Seoud O A, Koschella A, Fidale L C, et al. Biomacromolecules, 2007, 8: 2629-2646)。

发表论文

*为通讯作者

2015

1 Fen Wang, Xiao-Yu Guo, Dan-Ni Zhang, Yue Wu, Tao Wu, Zhi-Gang Chen*. Ultrasound- assisted extraction and purification of taurine from the red algae Porphyra yezoensis. Ultrasonics Sonochemistry, 24 (2015) 36–42

2014

1 Zhi-Gang Chen*, Dan-Ni Zhang, Qu Zhu, Qiu-Huizi Yang, Yong-Bin Han. Purification, preliminary characterization and in vitro immunomodulatory activity of tiger lily polysaccharide. Carbohydrate Polymers 106 (2014) 217–222

2 Dan-Ni Zhang, Xiao-Yu Guo, Qiu-Huizi Yang, Zhi-Gang Chen*, Li-Jia Tao.

An efficient enzymatic modification of cordycepin in ionic liquids under ultrasonic irradiation. Ultrasonics Sonochemistry 21 (2014) 1682–1687

3 Dan-Ni Zhang, Xiao-Yu Guo, Zhi-Gang Chen*. A novel and efficient method for the isolation and purification ofpolysaccharides from lily bulbs by Saccharomyces cerevisiae fermentation. Process Biochemistry 49 (2014) 2299–2304

2013

1 Zhi-Gang Chen*, Dan-Ni Zhang, Lin Cao, Yong-Bin Han. Highly efficient and regioselective acylation of pharmacologically interesting cordycepin catalyzed by lipase in the eco-friendly solvent 2-methyltetrahydrofuran.

Bioresource Technology 133 (2013) 82–86

2 Zhi-Gang Chen*, Dan-Ni Zhang, Yong-Bin Han. Lipase-catalyzed acylation of lily polysaccharide in ionic liquid-containing systems. Process Biochemistry 48 (2013) 620–624

3 Fen Wang, Zhi-Gang Chen*, Hui-Jie Zhu. An efficient enzymatic modification of lily polysaccharide in ionic liquid under ultrasonic irradiation. Biochemical Engineering Journal 79 (2013) 25– 28

4 Zhi-Gang Chen, Monika A Zie?tek, Henry J. Russell, Shirley Tait, Sam Hay, Alex R. Jones, and Nigel S. Scrutton. Dynamic, Electrostatic Model for the Generation and Control of High-Energy Radical Intermediates by a Coenzyme B12-Dependent Enzyme. ChemBioChem 2013, 14, 1529 – 1533

2011-2009

1 Chen Z.G. *, Zhu Q., Zong M.H., Gu Z.X., Han Y.B. Enzymatic synthesis and antibacterial activity of andrographolide derivatives. Process Biochemistry, 2011, 46, 1649-1653.

2 Chen Z.G.*, Tan R.X., Huang Mi. Efficient regioselective acylation of andrographolide catalyzed by immobilized Burkholderia cepacia lipase. Process Biochemistry, 2010, 45, 415-418.

3 Zhi Gang Chen*, Ren Xiang Tan and Lin Cao. Efficient and highly regioselective acylation of andrographolide catalyzed by lipase in acetone. Green Chemistry, 2009, 11, 1743–1745

4 Chen, Zhigang*, Zong, Minhua, Gu, Zhenxin. Toxicity, Biodegradability and Design and Synthesis of Green Ionic Liquids, Chinese Journal of Organic Chemistry,2009, 29(5):672-680

5 Zhi Gang Chen*, Ren Xiang Tan, Ming Huang. Efficient regioselective acylation of andrographolide catalyzed by Immobilized Burkholderia cepacia lipase. Process Biochemistry , 2010, 45, 415-418

6  Hongfei Yin, Zhigang Chen, Zhenxin Gu, Yongbin Han. Optimization of natural      fermentative medium for selenium-enriched yeast by D-optimal mixture design.

LWT - Food Science and Technology , 2009, 42(1): 327-331

2008-2006

1 Chen Z G, Zong M H, Gu Z X, Han Y B.  Effect of ultrasound on enzymatic

acylation of konjac glucomannan. Bioprocess Biosystem Engineering, 2008, 31:351–356

2 Xiaoxue Lu, Zhigang Chen, Zhenxin Gu, Yongbin Han. Isolation of γ-aminobutyric acid-producing bacteria and optimization of fermentative medium. Biochemical Engineering Journal , 2008, 41: 48-52

3 Chen Z G*, Han Y B, Gu Z X. Effect of ultrasonic irradiation on enzymatic

modification of  konjac   glucomannan. Polymer Preprints, 2007, 48(1), 394-395(Division of Polymer Chemistry,232th ACS National Meeting)

4 Chen, Zhi-Gang*, Zong, Min-Hua. Effects of molecular mass and acyl donors on enzymatic acylation of konjac glucomannan. Chinese Journal of Catalysis , 2007, 28(4): 339-344

5 Chen, Zhi-Gang*, Zong, Min-Hua, Gu, Zhen-Xin.  Enzymatic synthesis of sugar esters in ionic liquids. Chinese Journal of Organic Chemistry, 2007, 27(11): 1448-1452

6 陈志刚,宗敏华,娄文勇. 非水介质中酶促糖酯合成研究进展. 分子催化, 2007, 21(1): 90-95

7  Chen Z G, Zong M H, Li G J. Lipase-catalyzed regioselective acylation of konjac glucomannan in ionic liquids. Polymer Preprints, 2006, 47(1): 169-170

(Division of Polymer Chemistry,231th ACS National Meeting;Atlanta GA)

8 Chen Z G, Zong M H, Li G J. Lipase-catalyzed acylation of konjac glucomannan in organic media. Process Biochemistry (IF 2.414), 2006, 41(7): 1514-1520  

9 Chen Z G, Zong M H, Li G J. Lipase-catalyzed acylation of konjac glucomannan in ionic liquids. Journal of Chemical Technology & Biotechnology , 2006, 81(7): 1225-1231  

10  Chen Z G, Zong M H, Li G J. Lipase-Catalyzed Modification of Konjac Glucomannan. Journal of applied polymer science,2006, 102(2): 1335-1440

11Chen Z G, Zong M H, Li G J, Ding R. Lipase-catalyzed acylation of konjac glucomannan in a solvent-free system. Polymer Preprints, 2005, 46(2): 679-680

科研成果

授权专利

1、生物催化制备穿心莲内酯酯化衍生物的方法 ZL  200910033534.3

2、发酵法提取百合多糖的生产工艺及其产品 ZL  201010017677.8

3、一种即食性湿态调味紫菜产品及其生产工艺 ZL 200910024953.0

4、一种生物催化制备虫草素酯化衍生物的方法 ZL 201110163423.1

5、一种生物催化制备百合多糖酯化衍生物的方法 ZL 201210172982.3

6 一种同时有效去除紫菜提取液中紫菜蛋白和紫菜多糖的方法 ZL201310404659.9